FOUNDED BY: Tuscan Region Call Fas Salute 2018 Linea 3.6
PARTICIPATING INSTITUTIONS:
Azienda Ospedaliera Universitaria (coordinator) and University of Pisa
STARTING DATE: 03/08/2020
APPROVED END DATE: 02/02/2026
Giant cell tumor (GCT) represents 5% of all primitive bone tumors. Standard surgical treatment of GCT includes intralesional excision or segmental resection. The use of local adjuvants such as phenol, alcohol, H2O2, Argon, or cement as neoadjuvant therapy may decrease the recurrence rate, but which local adjuvant works best is still, to this day, controversial. Since tumor cells remain in the new-formed bone, the surgical technique of curettage has to be quite aggressive to avoid higher local recurrence rates. Cryoablation, a local treatment that induces coagulation necrosis, appears to be a good candidate because it is more aggressive than standard approaches. Cryoablation has already been used for treating not only GCT tumors but also for treating benign aggressive bone tumors, both as palliative treatment and as adjuvant therapy but its use as local adjuvant for treating GCT tumors has not been demonstrated as yet. The primary aim of the project is to assess the clinical efficacy of cryoablation as a local adjuvant in patients affected by GCT after intralesional surgery vs other adjuvants such as phenol. Clinical efficacy will be assessed in terms of a statistically significant reduction of local recurrence of disease in the first-year follow-up. Secondly, our goal is to compare the clinical outcomes of cryoablation with and without the aid of a dedicated surgical planning platform combined with a wearable Augmented Reality (AR) display. Finally, we shall lay down the specifications of an ideal planning and guidance AR framework that ensures safety and accuracy in cryoablation intending to design the most suitable AR visualization modality for guiding each surgical sub-task. To this end, we will develop the AR framework and evaluate its efficacy in an in-vitro study on patient-specific replicas.
TOTAL REQUESTED FUNDS: 345.020 €
UNIPI REQUESTED FUNDS:224.880 €
The research activity has resulted in the following main publications in peer-reviewed journals and contributions in conference proceedings:
- D’Arienzo A, Scognamiglio B, Campo FR, Cosseddu F, Ruinato DA, Ipponi E, Carbone M, Condino S, Ferrari V, Andreani L, Capanna R, Parchi PD. Preliminary Results of Preoperative Planning Using 3D Printing and Augmented Reality in Cryotherapy Treatment of Giant Cell Tumor of Bone-CRIO2AR Project. Healthcare (Basel). 2023 Sep 27;11(19):2629. doi: 10.3390/healthcare11192629. PMID: 37830669; PMCID: PMC10572172.
- Condino S, Cutolo F, Cattari N, Colangeli S, Parchi PD, Piazza R, Ruinato AD, Capanna R, Ferrari V. Hybrid Simulation and Planning Platform for Cryosurgery with Microsoft HoloLens. Sensors (Basel). 2021 Jun 29;21(13):4450. doi: 10.3390/s21134450. PMID: 34209748; PMCID: PMC8272062.
Received Prizes:
Best Poster at OTdigital Conference March 2018, Berlin